On the International Space Station (ISS), waste heat loads are removed by an Internal Active Thermal Control System (IATC) which is water based system. OPA is used in the IATCS water based system as a biocide to prevent negative impacts to coolant flow, heat transfer and corrosion, all of which could result in damage to IATCS and adversely affect crew health and safety. A simple inexpensive, National Institute of Standards and Technology (NIST) traceable process to analyze OPA that neither required highly hazardous chemicals nor involved a hazardous waste stream, was developed.